Research Program and Theme
- Program: Cancer Technology and Data Science
- Theme: Molecular Measurement
Research Focus
Joseph Irudayaraj’s lab has developed susceptible paper-based lateral flow technologies for rapid and onsite cervical cancer screening. Utilizing Fluorescence Lifetime Imaging (FLIM), Fluorescence Correlation Spectroscopy (FCS), and Darkfield hyperspectral imaging, Irudayaraj’s lab has monitored kinase phosphorylation in live cells, mRNA expression at splice variant resolution (BRCA1), and loci-specific epigenetic regulation – methylation and demethylation dynamics. His tools can assess drug response and toxicity in 2D and 3D cultures and model organisms such as sea elegans and zebrafish. His group is currently integrating super-resolution microscopy and deep tissue imaging to perform single-molecule experiments in living organisms. His lab’s interests are pancreatic cancer recurrence and Crohn’s disease, which are ongoing work collaborating with clinicians at the Carle Foundation Hospital. They have successfully developed nanosized cellulosic oxygen bubbles for hypoxia treatment to address a range of cancers. They have further shown that ultrasound can guide oxygen nanobubbles to enhance localization for targeted therapy and increase the efficacy of radiation and chemotherapy.
Learn more about Joseph Irudayaraj’s lab.
Other Campus Affiliations
- Professor, Materials Science and Engineering
- Professor, Micro and Nanotechnology Lab
- Professor, Biomedical and Translational Sciences
- Professor, Food Science and Human Nutrition
- Affiliate, Carl R. Woese Institute for Genomic Biology
- Professor, Beckman Institute for Advanced Science and Technology