Research
Joseph Irudayaraj’s lab has developed susceptible paper-based lateral flow technologies for rapid and onsite cervical cancer screening. Utilizing Fluorescence Lifetime Imaging (FLIM), Fluorescence Correlation Spectroscopy (FCS), and Darkfield hyperspectral imaging, Irudayaraj’s lab has monitored kinase phosphorylation in live cells, mRNA expression at splice variant resolution (BRCA1), and loci-specific epigenetic regulation – methylation and demethylation dynamics. His tools can assess drug response and toxicity in 2D and 3D cultures and model organisms such as sea elegans and zebrafish. His group is currently integrating super-resolution microscopy and deep tissue imaging to perform single-molecule experiments in living organisms. His lab’s interests are pancreatic cancer recurrence and Crohn’s disease, which are ongoing work collaborating with clinicians at the Carle Foundation Hospital. They have successfully developed nanosized cellulosic oxygen bubbles for hypoxia treatment to address a range of cancers. They have further shown that ultrasound can guide oxygen nanobubbles to enhance localization for targeted therapy and increase the efficacy of radiation and chemotherapy.
Education
- Ph.D., Biological Engineering, Purdue University.
Campus Affiliations
- Founder Professor, Bioengineering
- Professor, Bioengineering
- Professor, Materials Science and Engineering
- Professor, Micro and Nanotechnology Lab
- Professor, Biomedical and Translational Sciences
- Professor, Food Science and Human Nutrition
- Affiliate, Carl R. Woese Institute for Genomic Biology
- Professor, Beckman Institute for Advanced Science and Technology
- Associate Director for Shared Resources, Cancer Center at Illinois, Office of the Vice Chancellor for Research and Innovation
Select Honors and Recognitions
- AAAS Fellow, 2021
- AIMBE Fellow, 2014
- IAMBE Fellow, 2021
- Fellow of the Royal Society of Chemistry, 2021
Why I Study Cancer (or watch here)
A Closer Look at Joseph Irudayaraj’s Research (or watch here)
What You Might Not Know About Joseph Irudayaraj (or watch here)