David Shapiro

David Shapiro

Professor, Biochemistry

Research

David Shapiro’s lab has spent over a decade studying estrogens, acting via estrogen receptor a (ERa), which plays a key role in most breast cancers. The Shapiro laboratory has leveraged its expertise in ERa action in cancer to identify new pathways of hormone action that drive proliferation, metastases, and therapy resistance, and new types of selective anticancer therapeutics. Shapiro’s lab has identified a pathway conserved from insects to humans, and between steroid hormones and peptide hormones in which mitogenic hormones, such as estrogen, and epidermal growth factor (EGF), elicit extremely rapid anticipatory activation of the stress sensor, the unfolded protein response (UPR).

Education

  • Ph.D., Purdue University, 1972

Campus Affiliations