Research Program and Theme
- Program: Cancer Engineering and Biological Systems
- Theme: Mechanistic and Quantitative Biology
Research Focus
Brian Freeman’s research explores genomics, protein dynamics, protein-nucleic acid interactions, proteomics, and regulation of gene expression. More specifically, his lab investigates the impact of the Hsp90 molecular chaperone system on genomic pathways supporting homeostasis. Freeman’s independent research team developed a global p23-interaction network, revealing a large chaperone interactome in the nucleus. They are using this information to understand the events that control the dynamics of protein-DNA complexes within transcription-, telomere-, chromatin-, and chromosome-motion pathways.