Research Program and Theme
- Program: Cancer Engineering and Biological Systems
- Theme: Mechanistic and Quantitative Biology
Research Focus
Bo Wang’s laboratory focuses on understanding the molecular mechanisms underlying lipid metabolism and how these mechanisms contribute to human diseases such as cancer. His previous research has identified lysophosphatidylcholine acyltransferase 3 (Lpcat3) as a critical determinant of membrane phospholipid composition and biophysical properties. Lpcat3 catalyzes the incorporation of polyunsaturated fatty acids at the sn-2 site of lysophospholipids, giving rise to polyunsaturated phospholipids. The ability to manipulate membrane phospholipid composition in vivo by regulating Lpcat3 expression provides an unprecedented opportunity to study the consequences of altering membrane composition for homeostasis and disease pathogenesis in living animals. Learn more about Bo Wang’s lab.
Other Campus Affiliations
- Associate Professor, Nutritional Sciences
- Affiliate, Personalized Nutrition Initiative, Carl R. Woese Institute for Genomic Biology