Research Program and Theme
- Program: Cancer Technology and Data Science
- Theme: Molecular Measurement
Research Focus
Aleksei Aksimentiev studies the organization of DNA in cells to establish the molecular origins of cancer and drug resistance. His work connects atomic-scale structures of DNA and nucleosomes, their modifications, and drug resistance by characterizing the microscopic processes that lead to genome changes. He uses all-atom and coarse-grained molecular dynamics simulations to describe the mechanics of DNA, DNA binding to histone proteins in a nucleosome, and the self-association of distant DNA fragments mediated by physical forces. Learn more about Aleksei Aksimentiev’s lab.
Other Campus Affiliations
- Professor, National Center for Supercomputing Applications
- Affiliate, Carl R. Woese Institute for Genomic Biology
- Professor, Bioengineering
- Professor, Beckman Institute for Advanced Science and Technology