Research Program and Theme
- Program: Cancer Engineering and Biological Systems
- Theme: Anticancer Chemistry
Research Focus
Stephen Sligar has spent his professional career focused on the discovery, development, and use of chemical and biophysical tools to understand fundamental problems in biochemistry. Sligar’s lab developed the Nanodisc platform, which enables the generation of a soluble discoidal bilayer for presenting a membrane surface of defined composition and stability. With this technology, signaling proteins and macromolecular complexes that rely on a membrane for protein-protein and protein-lipid recognition can be studied using a range of biophysical tools to reveal the fundamental thermodynamic and kinetic mechanisms underlying signal transduction. Learn more about Stephen Sligar’s lab.
Other Campus Affiliations
- Research Professor, Biochemistry
- Professor Emeritus, Chemistry