Research Areas: Liver Cancer, Bile Acid
Research Program: Cancer Discovery Platforms Bridging the Engineering-Biology Continuum
Strategic Theme: Pathways & Mechanisms
Sayeepriyadarshini (Sayee) Anakk focuses on understanding liver metabolism in both normal and diseased states. She aims to investigate how bile acids and nuclear receptors maintain metabolic homeostasis and contribute to liver diseases, including cancer, using cell-based systems and genetically engineering mouse models. Other topics that she researches are the molecular mechanisms that control gender-specific drug metabolism, nuclear receptor signaling, and its relationship with both biliary homeostasis and adipogenesis and bile acids that signal to Hippo pathways and cause hepatocellular carcinoma.
Anakk, Ph.D., received her BS in Pharmacy and MSc in Biological Sciences from the Birla Institute of Technology Sciences, Pilani, India, and her Ph.D. in Biochemistry from the University of Texas, Graduate School of Biomedical Sciences at Houston. She worked as a Postdoctoral Fellow at the Baylor College of Medicine in Houston. She is an Associate Professor in the Department of Molecular and Integrative Physiology, the Division of Nutritional Sciences, and at the Beckman Institute for Advanced Science and Technology.