Research Program and Theme
- Program: Cancer Engineering and Biological Systems
- Theme: Mechanistic and Quantitative Biology
Research Focus
Kannanganattu Prasanth’s laboratory has significantly contributed to understanding the role of lncRNAs in gene expression. His lab explores the molecular mechanisms by which the oncogenic lncRNA MALAT1 regulates alternative splicing (AS) of pre-mRNA and uses hypoxia response in breast cancer cells as an experimental model system. The current application builds logically on his prior work, describing the role of lncRNAs in gene regulation and their involvement in cancer. His lab was the first to demonstrate MALAT1’s role in alternative splicing (AS) of pre-mRNAs.