Research Program: Cancer Measurement Technology and Data Science
Strategic Theme: Molecular Measurement
Pablo Perez-Pinera has a broad background and extensive experience in genome engineering, gene editing, and regulation of gene expression with artificial transcription factors. Perez-Pinera’s work has been critical for
understanding activation of native gene expression using TALEs or CRISPR artificial transcription factors, and his lab has developed gene editing tools for correction of Duchenne muscular dystrophy or the generation of gene editing tools targeting the ROSA26 locus for mouse transgenesis. The Perez-Pinera laboratory is actively developing next-generation genome engineering platforms to advance towards cures for genetic diseases including using these techniques to create model cell lines for understanding cancer progression as well as to develop therapies for treating glioblastomas.
Perez-Pinera is also faculty within the “Anticancer Discovery from Pets to People” theme in the Carl R. Woese Institute for Genomic Biology and affiliate faculty in the Carle Illinois College of Medicine. He earned an MD as well as a PhD degree in Biochemistry from the University of Oviedo in Spain.