Lin-Feng Chen researches infections that cause gastric cancer and other types of cancers. His research has uncovered Helicobacter pylori, a common stomach infection, causes gastritis, peptic ulceration, and is the strongest risk factor for the development of gastric cancer. The Chen lab also studies the regulation and function of Bromodomain-containing protein 4 (Brd4) in cancer and immunity. It is a regulator of NF-κB-mediated inflammatory response and cancer development. Chen’s research has demonstrated that small molecules inhibiting Brd4 have strong anti-tumor and anti-inflammatory activities. His research will help develop new therapeutic cancer and inflammatory disease treatments.
Lin-Feng Chen received his BS from Xiamen University, China in 1987 and his MS from Peking Union Medical University in 1990. In 1999, he received his PhD from Kyoto University in Japan. He did his postdoctoral training at Gladstone Institute of Immunology and Virology and the University of California in San Francisco from 1999-2003. He is currently a Professor of Biochemistry and a Professor of Pathology at the University of Illinois Urbana-Champaign and a Professor at the Carl R. Woese Institute for Genomic Biology.