RNA polymerase III (Pol III) upregulation is a hallmark of cancer, suggesting increased Pol III activity, which produces tRNA, 5S rRNA, and other small RNA species needed for protein accumulation, is a requirement for cancer cell proliferation. Using a combinatorial...
Sandra Rodriguez-Zas is helping find ways to prevent and cure diseases in both livestock and humans. She uses biostatistics and computational approaches to identify biomarkers and molecular pathways associated with health, reproduction, and performance in livestock...
Supriya Prasanth’s laboratory is focused on understanding how replication initiation is coordinated with chromatin organization and cell cycle progression. Defects in accurate replication and faithful chromosome segregation cause genomic instability, a hallmark...
Sihai Dave Zhao conducts methodological research focused on developing rigorous statistical techniques for analyzing large-scale data from high-throughput genetics and genomics experiments. His current work centers on procedures for the integrative analysis of...
Jun Song is interested in applying his training in mathematics and physics to problems in biomedical research – he has been applying his computational skills to genomics and epigenomics for over a decade. Song’s research focuses on understanding the...
Brian Freeman’s research explores genomics, protein dynamics, protein-nucleic acid interactions, proteomics, and regulation of gene expression. More specifically, his lab investigates the impact of the Hsp90 molecular chaperone system on genomic pathways...
Auinash Kalsotra’s laboratory is focused on answering one fundamental question in biology: How do cells produce the precise assortment of RNAs and proteins in space and time to carry out complex tissue functions? Kalsotra is particularly interested in understanding...
Saurabh Sinha’s research falls into the area of computational regulatory genomics and big data genomics. His lab group is currently working on quantitative modeling of regulatory sequences (NIGMS R01 grant, 2015-18), with the goal of predicting gene expression levels...
Lawrence Schook is an international scholar of comparative genomics who has developed the Oncopig Cancer Model, a biomedical cancer model to help medical professionals better understand and treat the disease. The Oncopig Cancer Model (OCM) is a next-generation large...
