Michael Spinella’s laboratory is focused on the molecular genetics of cancer, especially in the areas of mechanisms of tumorigenesis, cancer therapy, and drug resistance. One research focus is on uncovering mechanisms that account for the curability of...
Douglas Mitchell and his lab group have focused on understanding the chemical biology of natural products with early efforts focusing on thiazole/oxazole-containing peptides. The Mitchell lab is multidisciplinary and employs a combination of bioinformatics,...
David Kranz’s lab been involved for many years in the discovery of immunotherapeutic approaches to cancer. The research program he leads is focused on the structure, function, and engineering of T cell receptors. The Kranz lab is interested in understanding the...
Stephen Sligar has spent his professional career focused on the discovery, development, and use of chemical and biophysical tools to understand fundamental problems in biochemistry. Sligar’s lab developed the Nanodisc platform, which allows for the generation of a...
David Shapiro’s lab has spent over a decade studying estrogens, acting via estrogen receptor a (ERa), which plays a key role in most breast cancers. The Shapiro laboratory has leveraged its expertise in ERa action in cancer to identify new pathways of hormone action...
David Sarlah is an organic chemist, using the discovery of new reactivities and the guiding principles of chemistry to aid in the creation of cancer therapies. Through collaborations with CCIL members, Sarlah has successfully developed several enabling methodologies...
Paul J. Hergenrother, Ph.D., is a Professor of Chemistry and an Affiliate in Biochemistry, and the Kenneth L. Rinehart Jr. Endowed Chair in Natural Products Chemistry. The Hergenrother laboratory seeks to use small molecules to identify and validate novel targets for...
Martin Burke’s research interests are in organic chemistry with a specific focus on synthesizing and studying small molecules with protein-like functions. His research includes “Lego Chemistry,” which synthesizes small molecules for scientific research through amino...
