RNA polymerase III (Pol III) upregulation is a hallmark of cancer, suggesting increased Pol III activity, which produces tRNA, 5S rRNA, and other small RNA species needed for protein accumulation, is a requirement for cancer cell proliferation. Using a combinatorial...
Supriya Prasanth’s laboratory is focused on understanding how replication initiation is coordinated with chromatin organization and cell cycle progression. Defects in accurate replication and faithful chromosome segregation cause genomic instability, a hallmark...
Prasanth Kannanganattu’s laboratory has significantly contributed to understanding lncRNA’s role in gene expression. His lab explores the molecular mechanism by which the oncogenic lncRNA, MALAT1, controls alternative splicing (AS) of pre-mRNA and...
Brian Freeman’s research explores genomics, protein dynamics, protein-nucleic acid interactions, proteomics, and regulation of gene expression. More specifically, his lab investigates the impact of the Hsp90 molecular chaperone system on genomic pathways supporting...
Paul Selvin has spent his career developing high-resolution fluorescent techniques to study biological molecules as a biophysicist. Selvin’s recent work has turned to molecular motors—proteins whose job is moving cargoes around the cell. Selvin’s lab is now...
Chen received her BS in Biology from Peking University in China and her Ph.D. in Biochemistry from Rice University. She completed her postdoctoral training at Harvard University. Chen is a professor of cell and developmental biology and biomedical and translational...
