Huimin Zhao’s research develops and applies synthetic biology, machine learning, and laboratory automation tools to engineer functionally improved or novel proteins, pathways, and genomes for biotechnological and biomedical applications. Zhao investigates the...
Samy Meroueh develops small molecules that modulate the function of proteins that are considered undruggable, such as members of the RAS and Rho GTPase superfamily, transcription factors and co-activators such as Hippo pathway TEAD and YAP, and proteins involved in...
Wu’s lab mainly focuses on the biophysical characterization of antibody-antigen interaction. Through high-throughput screening and biophysical characterization of antibody variants, his lab’s research provides insights into the mechanisms of antibody...
Kai Zhang’s lab group studies how signal transduction regulates cell fate determination and how normal signaling processes are compromised in disease conditions. Using live cell imaging and optogenetic control of signal transduction, Zhang observes and perturbs...
Emad Tajkhorshid’s lab group has established an extensive research program in developing and applying molecular modeling and simulation technologies to the investigation of structure- and dynamics-function relationships in membrane proteins and characterization...
Satish Nair’s lab focuses on understanding the basis for regulation of bacteria by small molecule natural products. His laboratory uses classical biochemical and microbiological techniques, in combination with biophysical methods (in particular X-ray...
David Kranz’s lab been involved for many years in the discovery of immunotherapeutic approaches to cancer. The research program he leads is focused on the structure, function, and engineering of T cell receptors. The Kranz lab is interested in understanding the...
Raven Huang is interested in understanding how protein enzymes catalyze novel chemical reactions. His research focuses on drug discovery, enzymology, host-pathogen interactions, protein synthesis, protein-nucleic acid interactions, RNA biology, and toxins. Since Huang...
Hong Jin has broad training in biochemistry, biophysics, and structural biology, including macromolecule X-ray crystallography, solution NMR spectroscopy, and electron cryo-microscopy. Her lab’s goal is to understand the mechanisms of essential RNA-protein complexes...
Auinash Kalsotra’s laboratory focuses on answering one fundamental question in biology: How do cells produce the precise assortment of RNAs and proteins in space and time to carry out complex tissue functions? Kalsotra is particularly interested in understanding how...
Stephen Sligar has spent his professional career focused on the discovery, development, and use of chemical and biophysical tools to understand fundamental problems in biochemistry. Sligar’s lab developed the Nanodisc platform, which allows for the generation of a...
David Shapiro’s lab has spent over a decade studying estrogens, acting via estrogen receptor a (ERa), which plays a key role in most breast cancers. The Shapiro laboratory has leveraged its expertise in ERa action in cancer to identify new pathways of hormone action...
