Research Ranoa uses CAR-T cells directed against tumors that display dysregulated antigens on their surface as a model system, perform in vitro co-culture assays and set up in vivo tumor models using both immune-competent and immuno-deficient mice. Common techniques...
Research Wilfred van der Donk’s research program focuses on the discovery and design of new antibiotics and natural products. These projects combine synthetic organic and protein chemistry to address problems at the interface of chemistry and biology. Education...
Samy Meroueh develops small molecules that modulate the function of proteins that are considered undruggable, such as members of the RAS and Rho GTPase superfamily, transcription factors and co-activators such as Hippo pathway TEAD and YAP, and proteins involved in...
Research Chitra Subramanian is a biomedical research scientist with experience in preclinical drug development, technology licensing, and project management.
Research Mark Cohen was previously a professor of surgery and pharmacology at the University of Michigan, where he also served as the director of the Medical School Pathway of Excellence in Innovation and Entrepreneurship and the director of endocrine surgery research...
Research The Mehta Lab is combining expertise in synthetic biology and synthetic chemistry to develop fundamentally novel, modular platforms to engineer selectivity in targeting cancers. They are using principles of directed evolution and biomolecule delivery...
Research Hee-Sun Han’s lab develops novel technologies integrating diverse chemical and physical principles to study intact, fully assembled biological systems with single cell/molecule resolution, at high throughput while retaining the spatial or environmental...
Research Kendrith M. Rowland is an oncologist at Carle Foundation Hospital and Carle Cancer Center. He manages Carle’s NCI Community Oncology Research Program, optimizing collaboration between cancer researchers and clinicians to improve cancer prevention...
Research Kai Zhang’s lab group studies how signal transduction regulates cell fate determination and how normal signaling processes are compromised in disease conditions. Using live cell imaging and optogenetic control of signal transduction, Zhang observes and...
Research Michael Spinella’s laboratory is focused on the molecular genetics of cancer, especially in the areas of mechanisms of tumorigenesis, cancer therapy, and drug resistance. One research focus is on uncovering mechanisms that account for the curability of...
Research David Kranz’s lab been involved for many years in the discovery of immunotherapeutic approaches to cancer. The research program he leads is focused on the structure, function, and engineering of T cell receptors. The Kranz lab is interested in...
Research Stephen Sligar has spent his professional career focused on the discovery, development, and use of chemical and biophysical tools to understand fundamental problems in biochemistry. Sligar’s lab developed the Nanodisc platform, which allows for the generation...
