Story originally from Molecular and Cellular Biology.
Jongsook Kim Kemper, Professor of Molecular and Integrative physiology, and her colleagues Sangwon Byun (co-first author), Sunmi Seok (co-first author), Young Kim (research scientist), and Peter Yau have published their recent findings in Nature Communications.
The study found a novel epigenetic pathway that promotes autophagy in mouse models by Fibroblast Growth Factor-21 and FGF21 signal-activated histone demethylase JMJD3. Kemper and the authors report that these findings could inform treatment for diseases linked with autophagy dysfunction, including cancer and neurodegenerative diseases. Learn more about the study.