Shiva Abbaszadeh

Photograph Abbaszadeh, Shiva
Biography

Dr. Abbaszadeh is an Assistant Professor in the Department of Nuclear, Plasma, and Radiological Engineering at the University of Illinois at Urbana-Champaign. The goal of her research is to develop state-of-the-art technology to provide the necessary tools to visualize and detect cancer at the molecular level, and to further our understanding of disease mechanisms. This research involves radiation detection and instrumentation for molecular imaging, computational problem solving, and quantitative characterization of biological processes. She previously developed a novel high-gain, high-resolution X-ray imaging detector that is currently being pursued for commercial use in low-dose mammography where maintaining excellent image quality at high spatial resolution is crucial. The proposed technology, based on direct conversion amorphous selenium, enables better detection of small tumors and facilitates early cancer diagnosis.

Shiva was also instrumental in the development of a high-resolution, high-sensitivity positron emission tomography (PET) system and associated signal processing algorithms. The preclinical system will enable imaging and evaluating novel molecular agents to improve the diagnosis and understanding of diseases. The next generation of high specificity molecular imaging probes have limited uptake, which often makes them difficult to visualize and quantify in PET. Example applications include monitoring cell trafficking for cancer metastasis and monitoring the interaction of the immune system and tumor cells over time. The proposed PET system is based on 3-D position-sensitive cadmium zinc telluride photon detectors, which have excellent spatial and energy resolution properties to address the challenging requirements for these applications.

Keywords

Molecular imaging, biosensors, early cancer detection, medical imaging instrumentation

Radiological Instrumentation Laboratory

Select Publications

  • New-generation small animal positron emission tomography system for molecular imaging. PMID: 28097211
  • Characterization of a sub-assembly of 3D position sensitive cadmium zinc telluride detectors and electronics from a sub-millimeter resolution PET system. PMID: 27551981
  • Enhanced detection efficiency of direct conversion X-ray detector using polyimide as hole-blocking layer. PMID: 24285255
  • Single-layer and dual-layer contrast-enhanced mammography using amorphous selenium flat panel detectors. PMID: 21852727
  • Including the effect of motion artifacts in noise and performance analysis of dual-energy contrast-enhanced mammography. PMID: 23202244
  • Evaluating noise reduction techniques while considering anatomical noise in dual-energy contrast-enhanced mammography. PMID: 23635274