Michael L. Oelze

Photograph
Biography

Dr. Oelze is an associate professor of Electrical and Computer Engineering at the University of Illinois at Urbana-Champaign (UIUC). He is an affiliate faculty of Bioengineering, Nuclear and Plasma Radiation Engineering, the Beckman Institute, and the Coordinates Science Laboratory at UIUC.

Dr. Oelze is interested in developing ultrasound for improved cancer diagnostics and developing ultrasound-based therapies for cancer. Specifically, Dr. Oelze has been involved with developing quantitative ultrasound techniques to improve the detection and classification of breast cancer and thyroid cancer. In the quantitative ultrasound techniques, the raw ultrasound backscattered signals from tissues are examined to extract information about the tissue microstructure that may raise the specificity of diagnosis. Quantitative ultrasound imaging techniques provide additional sources of image contrast over conventional ultrasound imaging. He has worked to implement these techniques on clinical imaging systems and worked with a company to develop ultrasound tomography for breast cancer diagnosis. He has also used these quantitative ultrasound techniques to monitor and assess the effects of cancer therapy on tumors. Specifically, Dr. Oelze has examined the ability of ultrasound to monitor application of thermal ablation and hyperthermia techniques on cancer and assess the acute response of tissues to these therapies. Using quantitative ultrasound imaging, thermal lesions can be visualized and correlated to a temperature. Related to this, Dr. Oelze has also been involved in ultrasound-based cancer therapies. For example, Dr. Oelze has helped develop techniques to synergistically enhance traditional cancer therapy techniques by first pre-sensitizing tumors using ultrasound-activated microbubbles. Microbubbles are used clinically as ultrasound contrast agents, are approved by the FDA, and are commercially available. The ultrasound-activated microbubbles target a specific tissue volume (e.g., a tumor) through localization of the ultrasound fields and the vasculature of the tissue volume is then perturbed by the oscillation and cavitation of the microbubbles. The result of the mechanical action of the microbubbles on a tumor volume is to make the volume more sensitive to the application of traditional cancer therapies like radiation, chemotherapy or hyperthermia.

Keywords

Cancer diagnostics, Quantitative ultrasound, Ultrasound-based cancer therapies

More Information

Visit http://www.brl.uiuc.edu/ to learn more about Dr. Oelze, or visit http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Search&db=pubmed&term=Oelze%20ML or http://www.brl.uiuc.edu/Publications/ for publication information.

*University of Illinois Cancer Center Member